Reaktion #724218

Reaktionsgleichung

1-(3,4,5-trimethoxybenzoyl)-3-phenyl-3-(2-methanesulfonyloxyethyl)pyrrolidine

N,N-diisopropylethylamine

methanol dichloromethane

4-(1-(2-ethoxyethyl)-1H-benzimidazol-2-yl)[1,4]diazepane hydriodic acid salt

→

title compound

1-(3,4,5-Trimethoxybenzoyl)-3-(2-(4-(1-(2-ethoxyethyl)-1H-benzimidazol-2-yl)[1,4]diazepan-1-yl)ethyl)-3-phenylpyrrolidine

Lösungsmittel

acetonitrile

ethyl acetate

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturHeat to reflux
2. 2
   ExtraktionExtract with a saturated aqueous sodium bicarbonate solution
3. 3
   TrocknenDry the organic layer over Na2SO4
4. 4
   Filtrationfilter
5. 5
   Sonstigeevaporate in vacuo
6. 6
   Sonstigeto give a residue
7. 7
   workup.ADDITIONCombine the product containing fractions
8. 8
   Sonstigeto give a residue
9. 9
   Filtrationfilter
10. 10
    SonstigeEvaporate the filtrate in vacuo

Vorschrift

Combine 1-(3,4,5-trimethoxybenzoyl)-3-phenyl-3-(2-methanesulfonyloxyethyl)pyrrolidine (prepared from (−)-3-phenyl-3-(2-hydroxyethyl)pyrrolidine(R,R)-di-p-anisoyltartaric acid salt) (5.5 g, 11.9 mmol), 4-(1-(2-ethoxyethyl)-1H-benzimidazol-2-yl)[1,4]diazepane hydriodic acid salt (7.0 g, 12.9 mmol), and N,N-diisopropylethylamine (9.0 mL, 51.4 mmol) in acetonitrile (100 mL). Heat to reflux. After 18 hours, cool to ambient temperature and dilute the reaction mixture with ethyl acetate (400 mL). Extract with a saturated aqueous sodium bicarbonate solution and then with brine. Dry the organic layer over Na2SO4, filter, and evaporate in vacuo to give a residue. Chromatograph the residue on silica gel eluting with 25% methanol/dichloromethane containing aqueous concentrated ammonia (20 mL/3 L). Combine the product containing fractions to give a residue. Dissolve the residue in dichloromethane and filter. Evaporate the filtrate in vacuo to give the title compound: mp; 43-48° C.

Quelle