Reaktion #724205

Reaktionsgleichung

1-(3,4,5-trimethoxybenzoyl)-3-(3,4-dichlorophenyl)-3-(2-oxoethyl)pyrrolidine

4-(1-(2-ethoxyethyl)-1H-benzimidazol-2-yl)[1,4]diazepane

sodium hydroxide

sodium cyanoborohydride

→

1-(3,4,5-Trimethoxybenzoyl)-3-(2-(4-(1-(2-ethyoxyethyl)-1H-benzimidazol-2-yl)[1,4]diazepan-1-yl)ethyl)-3-(3,4-dichlorophenyl)pyrrolidine

Lösungsmittel

methanol

ethyl acetate methanol

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.WAITAfter 18 hours
2. 2
   workup.STIRRINGstir
3. 3
   workup.WAITAfter 18 hours
4. 4
   Filtrationfilter
5. 5
   Sonstigeseparate the layers in the filtrate
6. 6
   Extraktionextract the organic layer with brine
7. 7
   TrocknenDry the organic layer over Na2SO4
8. 8
   Filtrationfilter
9. 9
   Sonstigeevaporate in vacuo
10. 10
    Sonstigeto give a residue
11. 11
    Sonstigeafter drying in vacuo at 82° C.

Vorschrift

Combine 1-(3,4,5-trimethoxybenzoyl)-3-(3,4-dichlorophenyl)-3-(2-oxoethyl)pyrrolidine (0.51 g, 1.13 mmol), 4-(1-(2-ethoxyethyl)-1H-benzimidazol-2-yl)[1,4]diazepane (0.40 g, 1.36 mmol), and silica gel (about 2 g) in methanol (24 mL) and stir. After 3 days, add sodium cyanoborohydride (0.71 g, 11.3 mmol) and 3 Å molecular sieves (about 12 g) and stir under an inert atmosphere. After 18 hours, add a solution of 2 M sodium hydroxide and dichloromethane and stir. After 18 hours, filter, separate the layers in the filtrate, and extract the organic layer with brine. Dry the organic layer over Na2SO4, filter, and evaporate in vacuo to give a residue. Chromatograph the residue on silica gel eluting with 1/1 ethyl acetate/methanol to give, after drying in vacuo at 82° C., the title compound: mp; 55-65° C. Rf=0.36 (silica gel, 1/1 ethyl acetate/methanol). Elemental Analysis calculated for C38H47Cl2N5O5: C 62.98; H 6.54; N 9.66; Found: C 62.65; H 6.65; N 9.51.

Quelle