Reaktion #723341

ord-333af5f0f1b840e18c6abaf4d8e71dba

Reaktionsgleichung

C[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)O
N-(3,5-difluorophenylacetyl)-L-alanine
COC(=O)[C@@H](N)Cc1ccc(O)cc1
L-tyrosine methyl ester
→
COC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)Cc1cc(F)cc(F)c1
title compound
COC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)Cc1cc(F)cc(F)c1
N-[N-(3,5-Difluorophenylacetyl)-L-alaninyl]-L-tyrosine Methyl Ester

Edukte

C[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)O
N-(3,5-difluorophenylacetyl)-L-alanine
COC(=O)[C@@H](N)Cc1ccc(O)cc1
L-tyrosine methyl ester
—
solid

Reagenzien

Keine

Lösungsmittel

—
EtOAc hexanes

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigethe product was purified by silica gel column chromatography

Vorschrift

Following General Procedure A and using N-(3,5-difluorophenylacetyl)-L-alanine (from Example B2 above) and L-tyrosine methyl ester (Bachem), the title compound was prepared as a solid (mp=85-88° C.). The reaction was monitored by tlc (Rf=0.27 in 50% EtOAc/hexanes) and the product was purified by silica gel column chromatography.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06191166B1uspto-grants-2001_02