Reaktion #723115

ord-a482bed599d74033aa2912600a21603e

Reaktionsgleichung

C1=C(c2c[nH]c3ccncc23)CC2CCCN2C1
3-(1,2,3,5,8,8a-hexahydro-7-indolizinyl)-1H-5-Azaindole
O=S(=O)(Cl)c1ccc2ccccc2c1
2-naphthalenesulfonyl chloride
C[Si](C)(C)[N-][Si](C)(C)C.[Na+]
NaN(TMS)2
→
O=S(=O)(c1ccc2ccccc2c1)n1cc(C2=CCN3CCCC3C2)c2cnccc21
3-(1,2,3,5,8,8a-Hexahydro-7-indolizinyl)-1-(2-naphthalenesulfonyl)-5-azaindole

Edukte

C1=C(c2c[nH]c3ccncc23)CC2CCCN2C1
3-(1,2,3,5,8,8a-hexahydro-7-indolizinyl)-1H-5-Azaindole
O=S(=O)(Cl)c1ccc2ccccc2c1
2-naphthalenesulfonyl chloride
C[Si](C)(C)[N-][Si](C)(C)C.[Na+]
NaN(TMS)2

Reagenzien

Keine

Lösungsmittel

C1CCOC1
THF

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigeat RT

Vorschrift

3-(1,2,3,5,8,8a-hexahydro-7-indolizinyl)-1H-5-Azaindole (10 mg, 0.0418 mmol), 2-naphthalenesulfonyl chloride (20 mg, 0.088 mmol) and 1M NaN(TMS)2 (100 μL, 0.10 mmol) in THF (0.5 mL) at RT.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06191141B1uspto-grants-2001_02