Reaktion #723071

Reaktionsgleichung

4-(4-fluorophenyl)-6-hydroxy-2-methylpyrimidine

phosphorus oxychloride

ammonia

→

title compound

4-Chloro-6-(4-fluorophenyl)-2-methylpyrimidine

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe mixture was refluxed for 1 hour
2. 2
   TemperaturThis reaction mixture was cooled
3. 3
   Sonstigethe crystals that separated out
4. 4
   Filtrationwere collected by filtration
5. 5
   WaschenThe crystals were washed with water
6. 6
   Sonstigedried

Vorschrift

To 21 g of 4-(4-fluorophenyl)-6-hydroxy-2-methylpyrimidine was added 63 ml of phosphorus oxychloride and the mixture was refluxed for 1 hour. This reaction mixture was cooled, poured into iced water, and neutralized with 28% aqueous ammonia and the crystals that separated out were collected by filtration. The crystals were washed with water and dried to provide 21 g of the title compound.

Quelle