Reaktion #722832

Reaktionsgleichung

4-chloro-2-methyl-6-phenylpyrrolo[3,2-d]pyrimidine

pyrrolidine

K2CO3

→

title compound

Ausbeute 53.0%

2-Methyl-6-phenyl-4-pyrrolidinylpyrrolo[3,2-d]pyrimidine

Ausbeute 53.0%

Lösungsmittel

H2O

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThis compound was prepared
2. 2
   SonstigeThe crude material was purified by flash chromatography on silica gel with 20:1 CHCl3

Vorschrift

This compound was prepared according to the method described in Example 2 by employing 4-chloro-2-methyl-6-phenylpyrrolo[3,2-d]pyrimidine (Example 1(e)) (70 mg, 0.287 mmol), pyrrolidine (Aldrich Chemical Company) (0.12 mL, 1.44 mmol) and K2CO3 (0.397 g, 2.87 mmol) in H2O (2 mL). The crude material was purified by flash chromatography on silica gel with 20:1 CHCl3:MeOH as eluant to give 42.1 mg (53%) of the title compound as an off-white solid. An analytical sample was obtained by recrystallization from EtOH. 1H NMR (CDCl3; 500 MHz): δ 2.07 (t, 4, J=6.3), 2.58 (s, 3), 3.88-3.90 (m, 4), 6.71 (s, 1), 7.36-7.46 (m, 3), 7.63 (d, 2, J=7.7). MS m/z: 279.5 (M+1), 277.5 (M−1). HRMS: Calcd for M+H: 279.1610. Found: 279.1613.

Quelle