Reaktion #72242

Reaktionsgleichung

HOBT

methyl cis(±)-3-(4-amino-3-methoxypiperidin-1-yl)-5-methoxybenzoate

Methyl cis(±)-3-(4-amino-3-methoxypiperidin-1-yl)-5-methoxybenzoate

4-chloro-5-ethyl-1H-imidazole-2-carboxylic acid

WSC hydrochloride

→

title compound

Ausbeute 88.0%

Methyl cis(±)-3-(4-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}-3-methoxypiperidin-1-yl)-5-methoxybenzoate

Ausbeute 88.0%

Lösungsmittel

dichloromethane

DMA

Reaktionsbedingungen

Vorschrift

The same operation as in Example (1g) was performed using methyl cis(±)-3-(4-amino-3-methoxypiperidin-1-yl)-5-methoxybenzoate obtained in Example (257c) (about 0.25 mmol), 4-chloro-5-ethyl-1H-imidazole-2-carboxylic acid obtained in Example (1d) (48 mg, 0.22 mmol), WSC hydrochloride (139 mg, 0.73 mmol), HOBT (49 mg, 0.36 mmol), dichloromethane (2 mL) and DMA (2 mL), to obtain 87 mg of the title compound (88%).

Quelle