Reaktion #72209

Reaktionsgleichung

4-aminopiperidine

ethyl 2-bromo-4-methylthiazole-5-carboxylate

diisopropylethylamine

→

title compound

Ausbeute 87.6%

Ethyl 2-(4-aminopiperidin-1-yl)-4-methyl-1,3-thiazole-5-carboxylate

Ausbeute 87.6%

Reaktionsbedingungen

Vorschrift

The same operation as in Example (237a) was performed using 4-aminopiperidine (0.19 mL, 1.80 mmol), ethyl 2-bromo-4-methylthiazole-5-carboxylate (300 mg, 1.20 mmol) and diisopropylethylamine (0.42 mL, 2.40 mmol), to obtain 283 mg of the title compound as a pale yellow oily substance (88%).

Quelle