Reaktion #72197

Reaktionsgleichung

ammonia

cis(±)-1-(diphenylmethyl)-2-ethylazetidin-3-yl methanesulfonate

cis(±)-1-(Diphenylmethyl)-2-ethylazetidin-3-yl methanesulfonate

→

title compound

cis(±)-1-(Diphenylmethyl)-2-ethylazetidin-3-amine

Lösungsmittel

isopropanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe reaction solution was concentrated under reduced pressure
2. 2
   workup.ADDITIONThen, saturated aqueous sodium bicarbonate solution was added to the resulting residue
3. 3
   Extraktionfollowed by extraction with chloroform
4. 4
   TrocknenThe combined organic layers were dried over anhydrous magnesium sulfate
5. 5
   Filtrationfiltered
6. 6
   EinengenThereafter, the filtrate was concentrated under reduced pressure

Vorschrift

28% aqueous ammonia (1.2 ml) was added to a solution of cis(±)-1-(diphenylmethyl)-2-ethylazetidin-3-yl methanesulfonate obtained in Example (235c) (315 mg, 0.91 mmol) in isopropanol (2 mL), and the mixture was stirred at 70° C. for four hours. The reaction solution was concentrated under reduced pressure. Then, saturated aqueous sodium bicarbonate solution was added to the resulting residue, followed by extraction with chloroform. The combined organic layers were dried over anhydrous magnesium sulfate and filtered. Thereafter, the filtrate was concentrated under reduced pressure to obtain 206 mg of the title compound as a pale yellow oily substance (85%).

Quelle