Reaktion #721966

ord-d25a98ac4d9144769005f8cb162b5b46

Reaktionsgleichung

O=C(Cc1ccccc1)NC1CCN(c2ccc(OCc3ccccc3)cc2)CC1
N-[1-(4-benzyloxy-phenyl)-piperidin-4-yl]-2-phenyl-acetamide
[Al+3].[H-].[H-].[H-].[H-].[Li+]
LiAlH4
→
c1ccc(CCNC2CCN(c3ccc(OCc4ccccc4)cc3)CC2)cc1
[1-(4-benzyloxy-phenyl)-piperidin-4-yl]-phenethyl-amine
Ausbeute 34.0%

Edukte

O=C(Cc1ccccc1)NC1CCN(c2ccc(OCc3ccccc3)cc2)CC1
N-[1-(4-benzyloxy-phenyl)-piperidin-4-yl]-2-phenyl-acetamide
[Al+3].[H-].[H-].[H-].[H-].[Li+]
LiAlH4

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Following the procedure of example 40b, N-[1-(4-benzyloxy-phenyl)-piperidin-4-yl]-2-phenyl-acetamide (200 mg) was reduced with LiAlH4 to give [1-(4-benzyloxy-phenyl)-piperidin-4-yl]-phenethyl-amine (65 mg; 34%) as a white solid (MS: m/e=387.3 (M+H+)).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06184236B2uspto-grants-2001_02