Reaktion #721964

ord-852b76282eb745b8ab49758a776d2f10

Reaktionsgleichung

CC1(C)CN(c2ccc(OCc3ccccc3)cc2)CCC1NC(=O)CCc1ccccc1
(RS)-N-[1-(4-benzyloxy-phenyl)-3,3-dimethyl-piperidin-4-yl]-3-phenyl-propionamide
[Al+3].[H-].[H-].[H-].[H-].[Li+]
LiAlH4
→
CC1(C)CN(c2ccc(OCc3ccccc3)cc2)CCC1NCCCc1ccccc1
(RS)-[1-(4-benzyloxy-phenyl)-3,3-dimethyl-piperidin-4-yl]-(3-phenyl-propyl)-amine

Edukte

CC1(C)CN(c2ccc(OCc3ccccc3)cc2)CCC1NC(=O)CCc1ccccc1
(RS)-N-[1-(4-benzyloxy-phenyl)-3,3-dimethyl-piperidin-4-yl]-3-phenyl-propionamide
[Al+3].[H-].[H-].[H-].[H-].[Li+]
LiAlH4

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Following the procedure of example 40b, (RS)-N-[1-(4-benzyloxy-phenyl)-3,3-dimethyl-piperidin-4-yl]-3-phenyl-propionamide (450 mg) was reduced with LiAlH4 to give (RS)-[1-(4-benzyloxy-phenyl)-3,3-dimethyl-piperidin-4-yl]-(3-phenyl-propyl)-amine as a white solid (260 mg; 60%, MS: m/e=429.4 (M+H+)).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06184236B2uspto-grants-2001_02