Reaktion #72192

Reaktionsgleichung

methanesulfonyl chloride

Triethylamine

trans(±)-1-(Diphenylmethyl)-2-ethylazetidin-3-ol

→

title compound

Ausbeute 90.9%

trans(±)-1-(Diphenylmethyl)-2-ethylazetidin-3-yl methanesulfonate

Ausbeute 90.9%

Lösungsmittel

dichloromethane

dichloromethane

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwashed with water and brine
2. 2
   Trocknendried over anhydrous magnesium sulfate
3. 3
   Filtrationfiltration
4. 4
   Einengenthe filtrate was concentrated under reduced pressure
5. 5
   SonstigeThe resulting residue was purified by silica gel column chromatography (elution solvent: hexane/ethyl acetate=5/1)

Vorschrift

Triethylamine (0.94 mL, 6.74 mmol) was added to a solution of trans(±)-1-(Diphenylmethyl)-2-ethylazetidin-3-ol obtained in Example (234b) (1.20 g, 4.49 mmol) in dichloromethane (8 mL). Then, a solution of methanesulfonyl chloride (0.45 mL, 5.83 mmol) in dichloromethane (1.5 mL) was added dropwise at room temperature, followed by stirring for four hours. The reaction solution was diluted with ethyl acetate, washed with water and brine, and then dried over anhydrous magnesium sulfate. Following filtration, the filtrate was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (elution solvent: hexane/ethyl acetate=5/1) to obtain 1.41 g of the title compound as a pale yellow oily substance (91%).

Quelle