Reaktion #721805

Reaktionsgleichung

4-Chloro-2-phenylquinazoline

potassium carbonate

→

product

2-Phenyl-4-(3-methoxyanilinyl)quinazoline

Lösungsmittel

isopropanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturrefluxed for 2 hours
2. 2
   SonstigeThe precipitated product formed
3. 3
   Filtrationwas filtered
4. 4
   Waschenwashed with water
5. 5
   SonstigeRecrystallization from methanol

Vorschrift

4-Chloro-2-phenylquinazoline, 2 equivalents, 3-methoxyanilinyl, 2 equivalents, and potassium carbonate, 2 equivalents, were dissolved in 10 mL isopropanol and refluxed for 2 hours. The precipitated product formed was filtered and washed with water. Recrystallization from methanol provided the product as a white solid that was found to be homogenous by thin layer chromatography (TLC) and confirmed by EIMS.

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