Reaktion #72122

Reaktionsgleichung

WSC hydrochloride

tert-butyl cis(±)-4-amino-3-(dimethylamino)piperidine-1-carboxylate

tert-Butyl cis(±)-4-amino-3-(dimethylamino)piperidine-1-carboxylate

4-chloro-5-ethyl-1H-imidazole-2-carboxylic acid

triethylamine

1-hydroxybenzotriazole hydrate

→

title compound

Ausbeute 69.4%

tert-Butyl cis(±)-4-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}-3-(dimethylamino)-piperidine-1-carboxylate

Ausbeute 69.4%

Reaktionsbedingungen

Vorschrift

The same operation as in Example (196b) was performed using tert-butyl cis(±)-4-amino-3-(dimethylamino)piperidine-1-carboxylate obtained in Example (200c) (93 mg, 0.382 mmol), 4-chloro-5-ethyl-1H-imidazole-2-carboxylic acid obtained in Example (1d) (80.1 mg, 0.459 mmol), 1-hydroxybenzotriazole hydrate (77.5 mg, 0.573 mmol), WSC hydrochloride (110 mg, 0.573 mmol) and triethylamine (79.9 μL, 0.573 mmol), to obtain 106 mg of the title compound (69%) as a colorless solid.

Quelle