Reaktion #72121

Reaktionsgleichung

hydrogen

tert-butyl cis(±)-4-{[(benzyloxy)carbonyl]amino}-3-(dimethylamino)piperidine-1-carboxylate

→

title compound

Ausbeute 100.3%

tert-Butyl cis(±)-4-amino-3-(dimethylamino)piperidine-1-carboxylate

Ausbeute 100.3%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe insoluble matter was separated by filtration
2. 2
   Einengenthe filtrate was concentrated under reduced pressure

Vorschrift

20% Palladium hydroxide (15 mg) was added to a solution of tert-butyl cis(±)-4-{[(benzyloxy)carbonyl]amino}-3-(dimethylamino)piperidine-1-carboxylate obtained in Example (200b) (144 mg, 0.381 mmol) in methanol (4 mL) at room temperature, and the mixture was stirred in a hydrogen atmosphere at 50° C. for six hours. The insoluble matter was separated by filtration, and the filtrate was concentrated under reduced pressure to obtain 93 mg of the title compound (100%) as a colorless oily substance.

Quelle