Reaktion #72116

Reaktionsgleichung

WSC hydrochloride

tert-butyl trans(±)-4-amino-3-fluoropiperidine-1-carboxylate

4-chloro-5-ethyl-1H-imidazole-2-carboxylic acid

triethylamine

1-hydroxybenzotriazole hydrate

→

title compound

Ausbeute 72.1%

tert-Butyl trans(±)-4-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}-3-fluoropiperidine-1-carboxylate

Ausbeute 72.1%

Reaktionsbedingungen

Vorschrift

The same operation as in Example (196d) was performed using tert-butyl trans(±)-4-amino-3-fluoropiperidine-1-carboxylate obtained in Example (197a) (30.0 mg, 0.137 mmol), 4-chloro-5-ethyl-1H-imidazole-2-carboxylic acid obtained in Example (1d) (28.8 mg, 0.165 mmol), 1-hydroxybenzotriazole hydrate (27.9 mg, 0.206 mmol), WSC hydrochloride (39.5 mg, 0.206 mmol) and triethylamine (28.7 μL, 0.206 mmol), to obtain 37.0 mg of the title compound (72%) as a pale yellow foamy substance.

Quelle