Reaktion #72113

Reaktionsgleichung

1-Hydroxybenzotriazole hydrate

WSC hydrochloride

triethylamine

tert-butyl cis(±)-4-amino-3-fluoropiperidine-1-carboxylate

4-chloro-5-ethyl-1H-imidazole 2-carboxylic acid

→

title compound

Ausbeute 75.2%

tert-Butyl cis(±)-4-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}-3-fluoropiperidine-1-carboxylate

Ausbeute 75.2%

Lösungsmittel

Water

DMA

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionfollowed by extraction with ethyl acetate
2. 2
   WaschenThe resulting organic layer was washed with water and brine
3. 3
   Trocknendried over anhydrous sodium sulfate
4. 4
   Sonstigethe insoluble matter was separated by filtration
5. 5
   EinengenThe filtrate was concentrated under reduced pressure
6. 6
   Sonstigethe resulting residue was purified by silica gel column chromatography (eluent: hexane:ethyl acetate=1:1 v/v)

Vorschrift

1-Hydroxybenzotriazole hydrate (114 mg, 0.845 mmol), WSC hydrochloride (162 mg, 0.845 mmol) and triethylamine (118 μL, 0.845 mmol) were added to a solution of tert-butyl cis(±)-4-amino-3-fluoropiperidine-1-carboxylate obtained in Example (196a) (123 mg, 0.564 mmol) and 4-chloro-5-ethyl-1H-imidazole 2-carboxylic acid obtained in Example (1d) (118 mg, 0.676 mmol) in DMA (3 mL) at room temperature, and the mixture was stirred at 70° C. for two hours. Water was added to the reaction solution, followed by extraction with ethyl acetate. The resulting organic layer was washed with water and brine, and dried over anhydrous sodium sulfate, and then the insoluble matter was separated by filtration. The filtrate was concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography (eluent: hexane:ethyl acetate=1:1 v/v) to obtain 159 mg of the title compound (75%) as a pale yellow foamy substance.

Quelle