Reaktion #721081

Reaktionsgleichung

3-(benzyloxy)-1-(diphenylmethyl)azetidine

3-(Benzyloxy)-1-(diphenylmethyl)azetidine

1,2-dichloroethane

1-Chloroethyl chloroformate

→

title compound

Ausbeute 92.0%

3-(Benzyloxy)azetidine hydrochloride

Ausbeute 92.0%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter cooling to room temperature
2. 2
   workup.STIRRINGthe reaction mixture was stirred at 70° C. for 1.5 h
3. 3
   TemperaturThe reaction mixture was cooled
4. 4
   Einengenconcentrated to dryness
5. 5
   SonstigeThe residue was purified on column chromatography (eluent: Pentane/NH3 7N in MeOH, 98/2)

Vorschrift

A 16 mL vial was charged with 3-(benzyloxy)-1-(diphenylmethyl)azetidine (103 mg, 0.31 mmol; which may be prepared as described in Step 1) and 1,2-dichloroethane (1.4 mL). 1-Chloroethyl chloroformate (45 μL, 0.41 mmol) was added and the reaction mixture was stirred at 70° C. for 1.5 h. After cooling to room temperature, methanol (1.4 mL) was added and the reaction mixture was stirred at 70° C. for 1.5 h. The reaction mixture was cooled and concentrated to dryness. The residue was purified on column chromatography (eluent: Pentane/NH3 7N in MeOH, 98/2) to give the title compound (57 mg, 92%).

Quelle