Reaktion #720949

Reaktionsgleichung

quinolin-5-ylmethanol

thionyl chloride

→

5-chloromethylquinoline hydrochloride

Lösungsmittel

ethyl ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturrefluxed for 2 hours
2. 2
   SonstigeThe reaction mixture is evaporated
3. 3
   Sonstigethe solid obtained
4. 4
   Filtrationthe solution is filtered
5. 5
   Waschenwashed with ethyl ether
6. 6
   Sonstigedried

Vorschrift

A solution of 190 mg (1.19 mmol) of quinolin-5-ylmethanol in 5 ml of thionyl chloride is stirred for 10 minutes at room temperature and then refluxed for 2 hours. The reaction mixture is evaporated, the solid obtained is taken up in ethyl ether and the solution is filtered, washed with ethyl ether and dried to give 255 mg of 5-chloromethylquinoline hydrochloride, corresponding to the following characteristics:

Quelle