Reaktion #72079

Reaktionsgleichung

Ethyl 6-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}-3-ethyl-1-benzothiophene-2-carboxylate

lithium hydroxide

→

title compound

Ausbeute 87.7%

6-{[(4-Chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}-3-ethyl-1-benzothiophene-2-carboxylic acid

Ausbeute 87.7%

Lösungsmittel

THF

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe organic solvent was evaporated under reduced pressure
2. 2
   FiltrationThe resulting solid was collected by filtration
3. 3
   Waschenwashed with distilled water and ethyl acetate
4. 4
   Sonstigedried under reduced pressure at 45° C.

Vorschrift

Ethyl 6-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}-3-ethyl-1-benzothiophene-2-carboxylate obtained in Example (183f) (49 mg) was dissolved in methanol (2 ml) and THF (2 ml). A 2 N aqueous lithium hydroxide solution (2 ml) was added, and the mixture was stirred at 50° C. for 30 minutes. The organic solvent was evaporated under reduced pressure, followed by neutralization with 1 N hydrochloric acid. The resulting solid was collected by filtration, washed with distilled water and ethyl acetate, and dried under reduced pressure at 45° C. to obtain 40 mg of the title compound as a solid.

Quelle