Reaktion #72072

Reaktionsgleichung

cesium carbonate

benzyl cis(±)-[3-methoxypiperidin-4-yl]carbamate

methyl 3-bromo-4-fluorobenzoate

BINAP

→

title compound

Ausbeute 61.5%

Methyl cis(±)-3-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)-4-fluorobenzoate

Ausbeute 61.5%

Reaktionsbedingungen

Vorschrift

The same operation as in Example (42a) was performed using benzyl cis(±)-[3-methoxypiperidin-4-yl]carbamate obtained in Example (160a) (100 mg, 0.38 mmol), methyl 3-bromo-4-fluorobenzoate (264 mg, 1.13 mmol), palladium acetate (25.5 mg, 0.11 mmol), BINAP (141 mg, 0.23 mmol) and cesium carbonate (370 mg, 1.13 mmol), to obtain 97.4 mg of the title compound as a yellow oily substance. mass spectrum (ESI): m/z 417 (M+H)+.

Quelle