Reaktion #72033
ord-f7084e78cd4e493192a1becde05d7c28
Reaktionsgleichung
cesium carbonate
benzyl cis(±)-[3-methoxypiperidin-4-yl]carbamate hydrochloride
ethyl 5-bromopyridine-3-carboxylate
BINAP
→
title compound
Ausbeute 51.2%
Ethyl cis(±)-5-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)pyridine-3-carboxylate
Ausbeute 51.2%
Edukte
Reagenzien
Reaktionsbedingungen
Detaillierte Bedingungen
See reaction.notes.procedure_details.
Vorschrift
The same operation as in Example (160b) was performed using benzyl cis(±)-[3-methoxypiperidin-4-yl]carbamate hydrochloride obtained in Example (160a) (832 mg, 2.76 mmol), ethyl 5-bromopyridine-3-carboxylate (530 mg, 2.3 mmol), palladium acetate (51.72 mg, 0.23 mmol), BINAP (286.89 mg, 0.46 mmol), and cesium carbonate (2.25 g, 6.91 mmol), to obtain 487 mg of the title compound as a yellow oily substance.