Reaktion #72029

ord-e17233dad78e4120994c97d845084c25

Reaktionsgleichung

CO[C@@H]1CN(C(=O)OC(C)(C)C)CC[C@@H]1NC(=O)OCc1ccccc1
tert-Butyl cis(±)-4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidine-1-carboxylate
CCOC(C)=O.Cl
hydrochloric acid ethyl acetate
→
CO[C@@H]1CNCC[C@@H]1NC(=O)OCc1ccccc1.Cl
title compound
CO[C@@H]1CNCC[C@@H]1NC(=O)OCc1ccccc1.Cl
Benzyl cis(±)-[3-methoxypiperidin-4-yl]carbamate hydrochloride

Edukte

CO[C@@H]1CN(C(=O)OC(C)(C)C)CC[C@@H]1NC(=O)OCc1ccccc1
tert-Butyl cis(±)-4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidine-1-carboxylate
CCOC(C)=O.Cl
hydrochloric acid ethyl acetate

Reagenzien

Keine

Lösungsmittel

CO
methanol

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    EinengenConcentration under reduced pressure

Vorschrift

tert-Butyl cis(±)-4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidine-1-carboxylate obtained in Example (40a) (800 mg, 2.2 mmol) was dissolved in methanol (40 mL). A 4 N hydrochloric acid/ethyl acetate solution (30 mL) was added, and the mixture was stirred at room temperature for one hour. Concentration under reduced pressure gave 691 mg of the title compound as a colorless oily substance (100%).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08536197B2uspto-grants-2013_09