Reaktion #720258

ord-1c3d4cc88e394a828e5169b49d261447

Reaktionsgleichung

O=C(O)c1ccc(C(=O)Nc2ccc(Cl)c(-c3ccccn3)c2)c(Cl)c1
3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid
CCNCC.Cl
diethylamine hydrochloride
→
CCN(CC)C(=O)c1ccc(C(=O)Nc2ccc(Cl)c(-c3ccccn3)c2)c(Cl)c1
2-chloro-N1-(4-chloro-3-(pyridin-2-yl)phenyl)-N4,N4-diethylterephthalamide

Edukte

O=C(O)c1ccc(C(=O)Nc2ccc(Cl)c(-c3ccccn3)c2)c(Cl)c1
3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid
CCNCC.Cl
diethylamine hydrochloride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThe product was purified on reverse phase HPLC

Vorschrift

75 mg of 3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzoic acid was coupled to diethylamine hydrochloride via Procedure G. The product was purified on reverse phase HPLC to yield 2-chloro-N1-(4-chloro-3-(pyridin-2-yl)phenyl)-N4,N4-diethylterephthalamide. MS (Q1) 443 (M)+.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09321761B2uspto-grants-2016_04