Reaktion #719896

Reaktionsgleichung

Formamidine acetate

diethyl-ethylmalonate

sodium ethoxide

→

5-ethylpyrimidine-4,6-diol

Lösungsmittel

ethanol

Reaktionsbedingungen

Vorschrift

Formamidine acetate was reacted with diethyl-ethylmalonate in the presence of sodium ethoxide in dry ethanol to yield 5-ethylpyrimidine-4,6-diol, which was converted to 4,6-Dichloro-5-ethylpyrimidine by POCl3 in the presence of TEA in toluene. 4,6-Dichloro-5-ethylpyrimidine was then reacted with aqueous ammonia in n-butanol at 100° C. to afford 4-amino-5-ethyl-6-chloropyrimidine.

Quelle