Reaktion #71955

Reaktionsgleichung

tert-butyl 3-hydroxy-4,4-dimethoxypiperidine-1-carboxylate

sodium hydride

3-chloro-2-methyl-1-propene

→

title compound

Ausbeute 76.9%

tert-Butyl 4,4-dimethoxy-3-[(2-methyl-2-propen-1-yl) oxy]piperidine-1-carboxylate

Ausbeute 76.9%

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe residue was purified by column chromatography (elution solvent: hexane/ethyl acetate=10/1, 4/1, 2/1)

Vorschrift

The same operation as in Example (90a) was performed using tert-butyl 3-hydroxy-4,4-dimethoxypiperidine-1-carboxylate (5.2 g, 20 mmol), sodium hydride (55% content, 1.31 g, 30 mmol), 3-chloro-2-methyl-1-propene (3.63 g, 40 mmol) and DMF (50 mL). The residue was purified by column chromatography (elution solvent: hexane/ethyl acetate=10/1, 4/1, 2/1) to obtain 4.85 g of the title compound as a colorless oily substance (77%).

Quelle