Reaktion #71935

Reaktionsgleichung

tert-butyl 3-allyloxy-4,4-dimethoxypiperidine-1-carboxylate

tert-Butyl 3-allyloxy-4,4-dimethoxypiperidine-1-carboxylate

water TFA

di-tert-butyl dicarbonate

→

title compound

Ausbeute 91.5%

tert-Butyl 3-allyloxy-4-oxopiperidine-1-carboxylate

Ausbeute 91.5%

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe resulting residue was purified by silica gel column chromatography (elution solvent: hexane/ethyl acetate=10/1, 5/1, 2/1, 1/1)

Vorschrift

The same operation as in Example (90b) was performed using tert-butyl 3-allyloxy-4,4-dimethoxypiperidine-1-carboxylate obtained in Example (113a) (5.64 g, 18.7 mmol), a water/TFA mixed solution (1/1, 35 mL) and di-tert-butyl dicarbonate (4.8 g, 22 mol). The resulting residue was purified by silica gel column chromatography (elution solvent: hexane/ethyl acetate=10/1, 5/1, 2/1, 1/1) to obtain 4.37 g of the title compound as a light brown oily substance (91%).

Quelle