Reaktion #71929

Reaktionsgleichung

THF

tert-butyl cis(±)-4-amino-3-ethoxypiperidine-1-carboxylate

tert-Butyl cis(±)-4-amino-3-ethoxypiperidine-1-carboxylate

sodium bicarbonate

benzyl chloroformate

→

title compound

Ausbeute 100.6%

tert-Butyl cis(±)-4-{[(benzyloxy)carbonyl]amino}-3-ethoxypiperidine-1-carboxylate

Ausbeute 100.6%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe residue was purified by silica gel column chromatography (elution solvent: ethyl acetate/hexane=1/4, 1/2, 1/1)

Vorschrift

The same operation as in Example (103a) was performed using tert-butyl cis(±)-4-amino-3-ethoxypiperidine-1-carboxylate obtained in Example (112d) (2.28 g, 11.4 mmol), sodium bicarbonate (1.26 g, 15 mmol), benzyl chloroformate (2.69 g, 15 mmol), THF (15 mL) and water (15 mL). The residue was purified by silica gel column chromatography (elution solvent: ethyl acetate/hexane=1/4, 1/2, 1/1) to obtain 4.34 g of the title compound as a colorless solid (100%).

Quelle