Reaktion #71873

Reaktionsgleichung

N-(3-methoxy-4-nitrobenzoyl)serine methyl ester

N-(3-Methoxy-4-nitrobenzoyl)serine methyl ester

Burgess reagent

→

title compound

Ausbeute 74.3%

Methyl 2-(3-methoxy-4-nitrophenyl)-4,5-dihydro-1,3-oxazole-4-carboxylate

Ausbeute 74.3%

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigePurification
2. 2
   Waschenby silica gel column chromatography (elution solvent: ethyl acetate/hexane=1/4, 1/2, 1/1, 1/2)

Vorschrift

The same operation as in Example (97b) was performed using N-(3-methoxy-4-nitrobenzoyl)serine methyl ester obtained in Example (102a) (2.46 g, 8.26 mmol), the Burgess reagent (2.56 g, 10.7 mmol) and THF (50 mL). Purification by silica gel column chromatography (elution solvent: ethyl acetate/hexane=1/4, 1/2, 1/1, 1/2) gave 1.72 g of the title compound as a light yellow solid (74%).

Quelle