Reaktion #71804

Reaktionsgleichung

WSC hydrochloride

tert-butyl cis(±)-4-amino-3-methoxypiperidine-1-carboxylate

Example ( 1e )

tert-Butyl cis(±)-4-amino-3-methoxypiperidine-1-carboxylate

HOBT

4,5-diiodoimidazole-2-carboxylic acid

→

title compound

Ausbeute 43.0%

tert-Butyl cis(±)-4-{[(4,5-diiodo-1H-imidazol-2-yl)carbonyl]amino}-3-methoxypiperidine-1-carboxylate

Ausbeute 43.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeobtained by the method

Vorschrift

The same operation as in Example (1g) was performed using tert-butyl cis(±)-4-amino-3-methoxypiperidine-1-carboxylate obtained by the method described in Example (1e) (170 mg, 0.74 mmol), 4,5-diiodoimidazole-2-carboxylic acid obtained in Example (71b) (about 0.34 mmol), WSC hydrochloride (195 mg, 1.02 mmol) and HOBT (46 mg, 0.34 mmol), to obtain 83.1 mg of the title compound as a white solid (43%).

Quelle