Reaktion #71782

Reaktionsgleichung

WSC hydrochloride

tert-butyl (3S,4R)-4-amino-3-methoxypiperidine-1-carboxylate

4-chloro-5-ethyl-1H-imidazole-2-carboxylic acid

HOBT

Example ( 1d )

4-Chloro-5-ethyl-1H-imidazole-2-carboxylic acid

→

title compound

Ausbeute 72.0%

tert-Butyl (3S,4R)-4-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}-3-methoxypiperidine-1-carboxylate

Ausbeute 72.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigesynthesized by the method

Vorschrift

The same operation as in Example (1g) was performed using tert-butyl (3S,4R)-4-amino-3-methoxypiperidine-1-carboxylate obtained in Example (56a) (224.4 mg, 0.96 mmol), 4-chloro-5-ethyl-1H-imidazole-2-carboxylic acid synthesized by the method described in Example (1d) (140 mg, 0.80 mmol), WSC hydrochloride (440 mg, 2.29 mmol) and HOBT (110 mg, 0.81 mmol), to obtain 222.4 mg of the title compound as a white solid (72%).

Quelle