Reaktion #71775

Reaktionsgleichung

WSC hydrochloride

tert-butyl cis(±)-3-(4-amino-3-ethoxypiperidin-1-yl)benzoate

tert-Butyl cis(±)-3-(4-amino-3-ethoxypiperidin-1-yl)benzoate

5-ethyl-4-(trifluoromethyl)-1H-imidazole-2-carboxylic acid

HOBT

Example ( 39e )

5-Ethyl-4-(trifluoromethyl)-1H-imidazole-2-carboxylic acid

→

title compound

Ausbeute 83.0%

tert-Butyl cis(±)-3-(4-{[(5-Ethyl-4-trifluoromethyl-1H-imidazol-2-yl)carbonyl]amino}-3-ethoxypiperidin-1-yl)benzoate

Ausbeute 83.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeobtained by the method

Vorschrift

The same operation as in Example (1g) was performed using tert-butyl cis(±)-3-(4-amino-3-ethoxypiperidin-1-yl)benzoate obtained in Example (48e) (about 0.22 mmol), 5-ethyl-4-(trifluoromethyl)-1H-imidazole-2-carboxylic acid obtained by the method described in Example (39e) (40 mg, 0.19 mmol), WSC hydrochloride (120 mg, 0.63 mmol) and HOBT (40 mg, 0.30 mmol), to obtain 81.0 mg of the title compound (83%).

Quelle