Reaktion #717554

Reaktionsgleichung

sodium carbonate

Acetic anhydride

Abiraterone

methanol

→

Abiraterone Acetate

Lösungsmittel

ethyl acetate

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstige(about 20 h)
2. 2
   Sonstigeis then reduced to about 50° C.
3. 3
   TemperaturThe resulting mixture is maintained
4. 4
   Temperaturcooled to room temperature
5. 5
   SonstigeThe phases are separated
6. 6
   workup.ADDITIONthe organic phase is treated with decolourising carbon
7. 7
   EinengenThe organic phase is then concentrated under vacuum
8. 8
   Sonstigeto obtain a sandy solid
9. 9
   Sonstigewhich is isolated by filtration (at 0-5° C.)
10. 10
    Sonstigedried under vacuum at 40° C. for 8 h (about 15 g)

Vorschrift

Acetic anhydride (70 g) is added to a suspension of Abiraterone (16 g) in ethyl acetate (48 mL) The mixture is heated to 70° C. until the reaction is complete (about 20 h); the temperature is then reduced to about 50° C. and methanol (28 mL) is added. The resulting mixture is maintained under stirring for 2 h, cooled to room temperature, and ethyl acetate (110 mL) and an aqueous solution of sodium carbonate (450 mL) are added. The phases are separated and the organic phase is treated with decolourising carbon. The organic phase is then concentrated under vacuum and the concentrate is taken up with acetonitrile (about 80 mL) to obtain a sandy solid, which is isolated by filtration (at 0-5° C.) and dried under vacuum at 40° C. for 8 h (about 15 g).

Quelle