Reaktion #71745

Reaktionsgleichung

2,2,2-Trifluoro-1-(2-methyl-1,3-dithian-2-yl)ethanone

dimethoxyacetaldehyde

ammonia

NCS

→

2-(Dimethoxymethyl)-5-methyl-4-(trifluoromethyl)-1H-imidazole

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.DISTILLATIONdistilled water (10 mL)
2. 2
   workup.STIRRINGthe mixture was stirred at room temperature for 18 hours
3. 3
   FiltrationThe reaction solution was filtered through celite
4. 4
   Einengenconcentrated under reduced pressure
5. 5
   SonstigeThe resulting compound was used for the next reaction without purification

Vorschrift

NCS (870 mg, 6.51 mmol) and silver nitrate (1.48 g, 8.71 mmol) were dissolved in acetonitrile (40 mL) and distilled water (10 mL). 2,2,2-Trifluoro-1-(2-methyl-1,3-dithian-2-yl)ethanone obtained in Example (36a) (500 mg, 2.17 mmol) was added, and the mixture was stirred for 40 minutes. Thereafter, dimethoxyacetaldehyde (5.76 M aqueous solution, 0.4 mL, 23.0 mmol) and 28% aqueous ammonia (2 mL) were added, and the mixture was stirred at room temperature for 18 hours. The reaction solution was filtered through celite and then concentrated under reduced pressure. The resulting compound was used for the next reaction without purification.

Quelle