Reaktion #71669

ord-a3f8ea28db254d8083a3c717ce3a13c7

Reaktionsgleichung

CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F
HBTU
CCN(C(C)C)C(C)C
DIPEA
O=S(=O)(c1ccc(C(F)(F)F)cc1)N1CCNCC1
1-{[4-(trifluoromethyl)phenyl]sulfonyl}piperazine
On1nnc2ccccc21
HOBT
Cc1ncccc1C(=O)O
2-methyl-3-pyridinecarboxylic acid
O
H2O
→
Cc1ncccc1C(=O)N1CCN(S(=O)(=O)c2ccc(C(F)(F)F)cc2)CC1
1-[(2-Methyl-3-pyridinyl)carbonyl]-4-{[4-(trifluoromethyl)phenyl]sulfonyl}piperazine

Edukte

CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[P-](F)(F)(F)(F)F
HBTU
CCN(C(C)C)C(C)C
DIPEA
O=S(=O)(c1ccc(C(F)(F)F)cc1)N1CCNCC1
1-{[4-(trifluoromethyl)phenyl]sulfonyl}piperazine
On1nnc2ccccc21
HOBT
Cc1ncccc1C(=O)O
2-methyl-3-pyridinecarboxylic acid
O
H2O

Reagenzien

Keine

Lösungsmittel

CN(C)C=O
DMF

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

To a solution of 1-{[4-(trifluoromethyl)phenyl]sulfonyl}piperazine (Description 1) (100 mg, 0.340 mmol) in DMF (5 ml) was added HOBT.H2O (52.0 mg, 0.340 mmol), HBTU (129 mg, 0.340 mmol), 2-methyl-3-pyridinecarboxylic acid (46.6 mg, 0.340 mmol) and DIPEA (0.178 ml, 1.019 mmol). The reaction mixture was stirred for 2 hours at room temperature.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08536183B2uspto-grants-2013_09