Reaktion #716464

Reaktionsgleichung

6-bromo-3-(2,4-difluoro-phenyl)-imidazo[1,2-a]pyridine

intermediate K

6-bromo-3-(2,4-difluoro-phenyl)-imidazo[1,2-a]pyridine

1-(4-fluoro-phenyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

intermediate A

1-(4-fluoro-phenyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

→

title compound

3-(2,4-Difluoro-phenyl)-6-[2-(4-fluoro-phenyl)-2H-pyrazol-3-yl]-imidazo[1,2-a]pyridine

Reaktionsbedingungen

Vorschrift

The title compound, white solid (56 mg, 44%), MS (ISP) m/z=391.5 [(M+H)+], mp 168° C., was prepared in accordance with the general method of example 1 from 6-bromo-3-(2,4-difluoro-phenyl)-imidazo[1,2-a]pyridine (intermediate K) (0.1 g, 0.324 mmol) and 1-(4-fluoro-phenyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (intermediate A) (0.11 mg, 0.38 mmol).

Quelle