Reaktion #71644

Reaktionsgleichung

1,1-Dimethylethyl (3S)-4-[(4-chlorophenyl)sulfonyl]-3-methyl-1-piperazinecarboxylate

→

title compound

(2S)-1-[(4-Chlorophenyl)sulfonyl]-2-methylpiperazine hydrochloride

Lösungsmittel

HCl

1,4-dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe sample was evaporated
2. 2
   Filtrationfiltered through a sinter
3. 3
   SonstigeThe collected solid was dried under vacuum at 40° C. for 18 hours

Vorschrift

1,1-Dimethylethyl (3S)-4-[(4-chlorophenyl)sulfonyl]-3-methyl-1-piperazinecarboxylate (may be prepared as described in Description 3) (crude weight 24.14 g, theoretical 49.9 mmol) was suspended in 4M HCl in 1,4-dioxane (80 mL, excess) and stirred vigorously for 3 hours. The sample was evaporated, suspended in diethyl ether (100 mL) and filtered through a sinter. The collected solid was dried under vacuum at 40° C. for 18 hours to yield the title compound as a yellow solid (15.45 g).

Quelle