Reaktion #71589

Reaktionsgleichung

(3-dibenzylamino-2-hydroxy-5-methyl-hexyl)-phosphonic acid dimethyl ester

→

(3-amino-2-hydroxy-5-methyl-hexyl)-phosphonic acid dimethyl ester

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeReaction 4
2. 2
   Sonstigeobtained in reaction 3
3. 3
   SonstigeThe mixture reaction
4. 4
   workup.WAITafter this period of time
5. 5
   Filtrationthe mixture was filtered through a pad of Celite
6. 6
   Sonstigethe solvents were removed under reduced pressure

Vorschrift

Reaction 4: A diastereomeric mixture of the crude (3-dibenzylamino-2-hydroxy-5-methyl-hexyl)-phosphonic acid dimethyl ester, compound 4, obtained in reaction 3, was treated with palladium-carbon (2.0% wt) as the catalyst in methanol (40 mL). The mixture reaction was stirred for 12 h under a hydrogen gas atmosphere at 37-42° C., and after this period of time, the mixture was filtered through a pad of Celite, and the solvents were removed under reduced pressure to leave (3-amino-2-hydroxy-5-methyl-hexyl)-phosphonic acid dimethyl ester, compound 5 as a crude oil.

Quelle