Reaktion #7158

Reaktionsgleichung

4-Hydroxy-3-methoxyphenylacetic acid pentafluorophenyl ester

Intermediate 2

3-(cyclohexen-1-yl)aniline

→

title compound

Ausbeute 86.0%

N-[3-(cyclohexen-1-yl)phenyl]-4-hydroxy-3-methoxyphenylacetamide

Ausbeute 86.0%

Lösungsmittel

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvent is evaporated under reduced pressure
2. 2
   Sonstigethe residue is purified by silica gel column chromatography (eluent: gradient from 0% to 100% hexane/ethyl acetate)

Vorschrift

4-Hydroxy-3-methoxyphenylacetic acid pentafluorophenyl ester (60 mg) and Intermediate 2 (60 mg) are dissolved in ethyl acetate, and the mixture is stirred at 60° C. for 18 hours. The solvent is evaporated under reduced pressure, and the residue is purified by silica gel column chromatography (eluent: gradient from 0% to 100% hexane/ethyl acetate) to give the title compound (50 mg).

Quelle