Reaktion #715616

Reaktionsgleichung

6-benzyl-4-chloro-1,7-dimethyl-6H-pyrrolo[2,3-e][1,2,4]triazolo[4,3-a]pyridine

N-(2-aminoethyl)morpholine

NaOtBu

(9,9-dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine)

→

6-Benzyl-1,7-dimethyl-N-(2-morpholin-4-ylethyl)-6H-pyrrolo[2,3-e][1,2,4]triazolo[4,3-a]pyridin-4-amine

Lösungsmittel

MeCN

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturUpon cooling
2. 2
   Filtrationfiltered
3. 3
   Sonstigepurified via preparative HPLC-MS (Waters XBridge C18
4. 4
   Wascheneluting with a gradient of MeCN/H2O containing 0.15% NH4OH)

Vorschrift

A degassed mixture of 6-benzyl-4-chloro-1,7-dimethyl-6H-pyrrolo[2,3-e][1,2,4]triazolo[4,3-a]pyridine (25 mg, 0.080 mmol, from Example 228, Step 7), N-(2-aminoethyl)morpholine (42 μL, 0.32 mmol, Aldrich), NaOtBu (15 mg, 0.16 mmol, Aldrich), (9,9-dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine) (9.3 mg, 0.016 mmol, Aldrich) and tris(dibenzylideneacetone)dipalladium(0) (7.4 mg, 0.0080 mmol, Aldrich) in toluene (1.2 mL) was heated at 100° C. overnight. Upon cooling, the reaction mixture was diluted with MeCN, filtered and purified via preparative HPLC-MS (Waters XBridge C18, eluting with a gradient of MeCN/H2O containing 0.15% NH4OH). Yield: (4.8 mg, 15%).

Quelle