Reaktion #71558

Reaktionsgleichung

4-nitrophenol

triethylamine

ethyl acetate

water

→

butyl 4-nitrophenyl carbonate

Lösungsmittel

tetrahydrofuran

butyl chloroformate

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturunder cooling on ice
2. 2
   SonstigeThe organic layer was separated
3. 3
   Waschenwashed with a saturated sodium chloride aqueous solution
4. 4
   Trocknendried over anhydrous magnesium sulfate
5. 5
   SonstigeAfter removing the solvent
6. 6
   Sonstigeby evaporation under reduced pressure

Vorschrift

Into a solution of 3.00 g of 4-nitrophenol and 3.31 mL of triethylamine in 30 mL of tetrahydrofuran, 2.75 mL of butyl chloroformate was dropped under cooling on ice. To the reaction mixture, after stirred at the same temperature for 10 min, ethyl acetate and water were added. The organic layer was separated, washed with a saturated sodium chloride aqueous solution, and dried over anhydrous magnesium sulfate. After removing the solvent by evaporation under reduced pressure, 4.60 g of butyl 4-nitrophenyl carbonate was obtained as a light yellow oily matter.

Quelle