Reaktion #71449

Reaktionsgleichung

8-(2,6-difluoro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid ethyl ester

5-imidazol-1-ylmethyl-pyridin-2-ylamine

NaHCO3

trimethyl aluminum

→

title compound

8-(2,6-Difluoro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid (5-imidazol-1-ylmethyl-pyridin-2-yl)-amide

Lösungsmittel

DCM

DCM MeOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe title compound was prepared in analogy to the procedure

Vorschrift

The title compound was prepared in analogy to the procedure described in Example 115 but using 8-(2,6-difluoro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid ethyl ester (Step 124.1), 5-imidazol-1-ylmethyl-pyridin-2-ylamine (Step 120.1), 2 equiv of trimethyl aluminum, stirring the reaction mixture for 3 h at 80° C. and pouring it onto a saturated aqueous solution of NaHCO3 and DCM. The title compound: ESI-MS: 503.1 [M+H]+; tR=3.76 min (System 1); TLC: Rf=0.47 (DCM/MeOH, 9:1).

Quelle