Reaktion #71446

Reaktionsgleichung

MeOH

8-(2,6-difluoro-3,5-dimethoxy-phenyl)quinoxaline-5-carboxylic acid ethyl ester

4-(2-Nitro-1H-imidazol-4-ylmethyl)morpholine

MeOH THF

→

title compound

8-(2,6-Difluoro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid (4-morpholin-4-ylmethyl-1H-imidazol-2-yl)-amide

Lösungsmittel

DCM MeOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe title compound was prepared in analogy to the procedures

Vorschrift

The title compound was prepared in analogy to the procedures described in Example 14 but stirring the reaction mixture for 2 h at 70° C. and using 8-(2,6-difluoro-3,5-dimethoxy-phenyl)quinoxaline-5-carboxylic acid ethyl ester (Step 124.1). 4-(2-Nitro-1H-imidazol-4-ylmethyl)morpholine (Step 23.1) was used instead of 2-nitroimidazole in Step 14.3, and Raney nickel and MeOH/THF (1:1) instead of palladium on carbon and MeOH in Step 14.2. The title compound: ESI-MS: 511.1 [M+H]+; tR=3.21 min (System 1); TLC: Rf=0.34 (DCM/MeOH/NH3aq, 94:5:1).

Quelle