Reaktion #71444

Reaktionsgleichung

8-(2,6-difluoro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid ethyl ester

4-(6-amino-pyridin-3-ylmethyl)-piperazin-2-one

NaHCO3

trimethyl aluminum

→

title compound

8-(2,6-Difluoro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid [5-(3-oxo-piperazin-1-ylmethyl)-pyridin-2-yl]-amide

Lösungsmittel

DCM

DCM MeOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe title compound was prepared in analogy to the procedure

Vorschrift

The title compound was prepared in analogy to the procedure described in Example 115 but using 8-(2,6-difluoro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid ethyl ester (Step 124.1), 4-(6-amino-pyridin-3-ylmethyl)-piperazin-2-one (Step 103.1), 1.5 equiv of trimethyl aluminum, stirring the reaction mixture for 7 h at 80° C. and pouring it onto a saturated aqueous solution of NaHCO3 and DCM. The title compound: ESI-MS: 535.1 [M+H]+; tR=3.50 min (System 1); TLC: Rf=0.16 (DCM/MeOH/NH3aq, 94:5:1).

Quelle