Reaktion #71422

Reaktionsgleichung

intermediate 100.2

(5-bromomethyl-pyridin-2-yl)-carbamic acid tert-butyl ester

3,3-dimethyl-piperazin-2-one

Cs2CO3

→

title compound

Ausbeute 67.7%

[5-(2,2-Dimethyl-3-oxo-piperazin-1-ylmethyl)-pyridin-2-yl]-carbamic acid tert-butyl ester

Ausbeute 67.7%

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigequenched by addition of H2O (500 mL)
2. 2
   Filtrationfiltered

Vorschrift

A mixture of intermediate 100.2 (Step 100.2) (18.4 g, 64 mmol), 3,3-dimethyl-piperazin-2-one (Step 108.4) (9 g, 70 mmol, 1.1 equiv) and Cs2CO3 (27.1 g, 83.2 mmol, 1.3 equiv) in DMF (75 ml) was stirred for 12 h at rt, quenched by addition of H2O (500 mL) and filtered to afford 14.5 g of the title compound as an off-white solid. Title compound: ESI-MS: 335.2 [M+H]+; tR=2.22 min (System 1).

Quelle