Reaktion #71418

Reaktionsgleichung

ethyl-2-bromoisobutyrate

ethylene diamine

potassium carbonate

→

title compound

Ausbeute 68.8%

3,3-Dimethyl-piperazin-2-one

Ausbeute 68.8%

Lösungsmittel

toluene

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturcooled
2. 2
   Filtrationfiltered
3. 3
   EinengenThe filtrate was concentrated
4. 4
   Sonstigethe residue triturated in Et2O

Vorschrift

A solution of ethyl-2-bromoisobutyrate (24 mL, 161 mmol) in toluene (150 mL) was added to a mixture of ethylene diamine (70 mL, 1046 mmol, 6.5 equiv) and potassium carbonate (24.4 g, 177 mmol, 1.1 equiv) in toluene (150 mL). The reaction mixture was heated for 20 h at 115° C., cooled and filtered. The filtrate was concentrated and the residue triturated in Et2O to afford 14.2 g of the title compound as a yellow solid: ESI-MS: 129.1 [M+H]+.

Quelle