Reaktion #71359

Reaktionsgleichung

1-methyl-4-(2-nitro-1H-imidazol-4-ylmethyl)-piperazine

8-naphthalen-1-yl-quinoxaline-5-carboxylic acid

8-Naphthalen-1-yl-quinoxaline-5-carboxylic acid [4-(4-methyl-piperazin-1-yl)-phenyl]-amide

MeOH THF

MeOH

→

Title compound

8-Naphthalen-1-yl-quinoxaline-5-carboxylic acid [4-(4-methyl-piperazin-1-ylmethyl)-1H-imidazol-2-yl]-amide

Lösungsmittel

DCM MeOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe title compound was prepared in analogy to the procedures

Vorschrift

The title compound was prepared in analogy to the procedures described in Example 14 but using 8-naphthalen-1-yl-quinoxaline-5-carboxylic acid (Example 46) in Step 14.1, Raney nickel and MeOH/THF (1:1) instead of palladium on carbon and MeOH in Step 14.2 and 1-methyl-4-(2-nitro-1H-imidazol-4-ylmethyl)-piperazine (Step 20.1) instead of 2-nitroimidazole in Step 14.3. Title compound: ESI-MS: 478.1 [M+H]+; tR=3.36 min (System 1); TLC: Rf=0.15 (DCM/MeOH, 9:1).

Quelle