Reaktion #7127

Reaktionsgleichung

(1S,2R)-2-(4-chlorobenzenesulfonylamino)-cyclohexanecarboxylic acid amide

1-bromomethyl-4-tert-butyl-benzene

→

titled compound

Ausbeute 69.0%

(1S,2R)-2-[(4-tert-Butyl-benzyl)-(4-chlorobenzenesulfonyl)-amino]-cyclohexanecarboxylic acid amide

Ausbeute 69.0%

Reaktionsbedingungen

Vorschrift

The titled compound was prepared in 69% yield from (1S,2R)-2-(4-chlorobenzenesulfonylamino)-cyclohexanecarboxylic acid amide (75 mg, 0.237 mmol) and 1-bromomethyl-4-tert-butyl-benzene (57 mg, 0.249 mmol) according to the procedure described for Example 3: 1H NMR (500 Mz, DMSO) δ 7.58 (d, 2 H, J=8.9), 7.48 (d, 2 H, J=8.6), 7.38 (br s, 1 H), 7.18 (d, 2 H, J=8.2), 7.09 (d, 2 H, J=8.2), 6.76 (br, s, 1 H), 4.53 (ABq, 2 H, Δv=39.4, Jab=16.2), 3. 95 (dt, 1 H, Jd=12.8, Jt=4.0), 2.80 (m, 1 H), 1.79 (m, 1 H), 1.72 (m, 1 H), 1.63 (m, 1 H), 1.48 (m, 2 H), 1.33 (m, 2 H), 1.25 (s, 9 H), 1.18 (m, 2 H); MS m/e 485.3 (M+Na)+.

Quelle