Reaktion #71245

ord-780fe064f98f4cc39f1925dfce3314e9

Reaktionsgleichung

CC1(c2csc(Cn3ncc(N)n3)n2)OCCO1
2-[4-(2-methyl-[1,3]dioxolan-2-yl)-thiazol-2-ylmethyl]-2H-[1,2,3]triazol-4-ylamine
O=C(O)/C=C/c1ccccc1C(F)(F)F
(E)-3-(2-trifluoromethyl-phenyl)-acrylic acid
→
CC(=O)c1csc(Cn2ncc(NC(=O)/C=C/c3ccccc3C(F)(F)F)n2)n1
(E)-N-[2-(4-Acetyl-thiazol-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-3-(2-trifluoromethyl-phenyl)-acrylamide

Edukte

CC1(c2csc(Cn3ncc(N)n3)n2)OCCO1
2-[4-(2-methyl-[1,3]dioxolan-2-yl)-thiazol-2-ylmethyl]-2H-[1,2,3]triazol-4-ylamine
O=C(O)/C=C/c1ccccc1C(F)(F)F
(E)-3-(2-trifluoromethyl-phenyl)-acrylic acid

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Following general procedure A followed by B, starting from 2-[4-(2-methyl-[1,3]dioxolan-2-yl)-thiazol-2-ylmethyl]-2H-[1,2,3]triazol-4-ylamine and (E)-3-(2-trifluoromethyl-phenyl)-acrylic acid.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08536209B2uspto-grants-2013_09