Reaktion #7124

Reaktionsgleichung

(1S,2S)-2-(4-chlorobenzenesulfonylamino)-cyclohexanecarboxylic acid

(1R,2S)-2-(4-chlorobenzenesulfonylamino)-cyclohexanecarboxylic acid amide

→

(1S,2S)-2-(4-Chlorobenzenesulfonylamino)-cyclohexanecarboxylic acid amide

Ausbeute 96.0%

Reaktionsbedingungen

Vorschrift

(1S,2S)-2-(4-Chlorobenzenesulfonylamino)-cyclohexanecarboxylic acid amide was synthesized from (1S,2S)-2-(4-chlorobenzenesulfonylamino)-cyclohexanecarboxylic acid (0.76 mmol) according to the method described for the preparation of (1R,2S)-2-(4-chlorobenzenesulfonylamino)-cyclohexanecarboxylic acid amide. The crude product (230 mg) was obtained in 96% yield and carried into the next reaction without purification: 1H NMR (300 Mz, CDCl3) δ 7.72 (d, 2 H, J=8.4), 7.42 (d, 2 H, J=8.8), 3.23 (m, 1 H), 2.13 (m, 1 H), 1.85 (m, 1 H), 1.65 (m,3 H), 1.42 (m, 1 H), 1.13 (m, 3 H); MS m/e 339 (M+Na)+.

Quelle